gene-e software (Broad Institute Inc)
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Broad Institute Inc
gene-e software
Gene E Software, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gene-e+software/gene+e+software/pmc10910089-112-5-8
Average 90 stars, based on 1 article reviews
Gene E Software, supplied by Broad Institute Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/gene-e+software/gene+e+software/pmc10910089-112-5-8
Average 90 stars, based on 1 article reviews
gene-e software - by Bioz Stars,
2026-10
90/100 stars
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Construct:Article Title: Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications Article Snippet: Normalized expression data were Log 2 transformed and loaded into the Gene-E software (v. 3.0.215, Broad Institute © 2013). Article Title: Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. Article Snippet: Based on previous reports on the significance of halogen moieties and the indenopyridin-5-one skeleton, we designed and synthesized a novel series of halogen (F , Cl , Br , CF3 and OCF3 )-containing 2,4diphenyl indenopyridin-5-ones and their corresponding -5-ols.. Unlike indenopyridin-5-ols, most of the prepared indenopyridin-5-ones with Cl , Br , and CF3 groups at the 2-phenyl ring conferred a strong dual topoisomerase I/IIa inhibitory effect.. Among the series, para-bromophenyl substituted compound 9 exhibited the most potent topoisomerase inhibition and antiproliferative effects, which showed dependency upon the topoisomerase gene expression level of diverse cancer cells. Article Title: Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL -Rearranged Acute Lymphoblastic Leukemia Article Snippet: Heatmaps were generated using Gene-E software (Broad Institute, Cambridge, MA, USA). Article Title: PBXIP1 - An indicator for poor outcome and metastatic spread in colorectal cancer. Article Snippet: Tumor cell heterogeneity in colorectal cancers within the same genetic background is a well-described phenomenon.. In this work, we investigate the role of hematopoietic pre-B-cell leukemia transcription factor (PBX)interacting protein (HPIP/PBXIP1) in tumor cell subpopulations with differential Wingless-related integration site (WNT) activity as well as its potential associations with epithelial-mesenchymal transition (EMT) and clinical associations in colorectal cancer.. We used in situ analyses to identify immunohistochemical expression of PBXIP1 in normal and colorectal cancer tissues and biostatistical approaches to determine its function and regulatory correlations. Article Title: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Article Snippet: 1Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.. 2Discovery 1 team, GI Innovation, Seoul, Korea.. 3Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Korea. Article Title: Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair Article Snippet: Heat maps were constructed using GENE-E software (The Broad Institute, www.broadinstitute.org/cancer/software/GENE-E/ ). Article Title: Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Article Snippet: Prostate cancer patients primarily receive androgen receptor (AR)-targeted drugs as a primary treatment option because prostate cancer is associated with highly activated AR signaling.. AR amplification made prostate cancer cells viable under treatment of AR-targeted therapy, leading to castration resistance.. AR amplification was more common in enzalutamide-resistant patients. Article Title: Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters Article Snippet: Heat maps were generated using the GENE-E software (Broad Institute, Cambridge, MA, USA). Software:Article Title: Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications Article Snippet: Normalized expression data were Log 2 transformed and loaded into the Gene-E software (v. 3.0.215, Broad Institute © 2013). Article Title: Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. Article Snippet: Based on previous reports on the significance of halogen moieties and the indenopyridin-5-one skeleton, we designed and synthesized a novel series of halogen (F , Cl , Br , CF3 and OCF3 )-containing 2,4diphenyl indenopyridin-5-ones and their corresponding -5-ols.. Unlike indenopyridin-5-ols, most of the prepared indenopyridin-5-ones with Cl , Br , and CF3 groups at the 2-phenyl ring conferred a strong dual topoisomerase I/IIa inhibitory effect.. Among the series, para-bromophenyl substituted compound 9 exhibited the most potent topoisomerase inhibition and antiproliferative effects, which showed dependency upon the topoisomerase gene expression level of diverse cancer cells. Article Title: Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL -Rearranged Acute Lymphoblastic Leukemia Article Snippet: Heatmaps were generated using Gene-E software (Broad Institute, Cambridge, MA, USA). Article Title: PBXIP1 - An indicator for poor outcome and metastatic spread in colorectal cancer. Article Snippet: Tumor cell heterogeneity in colorectal cancers within the same genetic background is a well-described phenomenon.. In this work, we investigate the role of hematopoietic pre-B-cell leukemia transcription factor (PBX)interacting protein (HPIP/PBXIP1) in tumor cell subpopulations with differential Wingless-related integration site (WNT) activity as well as its potential associations with epithelial-mesenchymal transition (EMT) and clinical associations in colorectal cancer.. We used in situ analyses to identify immunohistochemical expression of PBXIP1 in normal and colorectal cancer tissues and biostatistical approaches to determine its function and regulatory correlations. Article Title: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Article Snippet: 1Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.. 2Discovery 1 team, GI Innovation, Seoul, Korea.. 3Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Korea. Article Title: Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair Article Snippet: Heat maps were constructed using GENE-E software (The Broad Institute, www.broadinstitute.org/cancer/software/GENE-E/ ). Article Title: Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Article Snippet: Prostate cancer patients primarily receive androgen receptor (AR)-targeted drugs as a primary treatment option because prostate cancer is associated with highly activated AR signaling.. AR amplification made prostate cancer cells viable under treatment of AR-targeted therapy, leading to castration resistance.. AR amplification was more common in enzalutamide-resistant patients. Article Title: Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters Article Snippet: Heat maps were generated using the GENE-E software (Broad Institute, Cambridge, MA, USA). Generated:Article Title: Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications Article Snippet: Normalized expression data were Log 2 transformed and loaded into the Gene-E software (v. 3.0.215, Broad Institute © 2013). Article Title: Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. Article Snippet: Based on previous reports on the significance of halogen moieties and the indenopyridin-5-one skeleton, we designed and synthesized a novel series of halogen (F , Cl , Br , CF3 and OCF3 )-containing 2,4diphenyl indenopyridin-5-ones and their corresponding -5-ols.. Unlike indenopyridin-5-ols, most of the prepared indenopyridin-5-ones with Cl , Br , and CF3 groups at the 2-phenyl ring conferred a strong dual topoisomerase I/IIa inhibitory effect.. Among the series, para-bromophenyl substituted compound 9 exhibited the most potent topoisomerase inhibition and antiproliferative effects, which showed dependency upon the topoisomerase gene expression level of diverse cancer cells. Article Title: Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL -Rearranged Acute Lymphoblastic Leukemia Article Snippet: Heatmaps were generated using Gene-E software (Broad Institute, Cambridge, MA, USA). Article Title: PBXIP1 - An indicator for poor outcome and metastatic spread in colorectal cancer. Article Snippet: Tumor cell heterogeneity in colorectal cancers within the same genetic background is a well-described phenomenon.. In this work, we investigate the role of hematopoietic pre-B-cell leukemia transcription factor (PBX)interacting protein (HPIP/PBXIP1) in tumor cell subpopulations with differential Wingless-related integration site (WNT) activity as well as its potential associations with epithelial-mesenchymal transition (EMT) and clinical associations in colorectal cancer.. We used in situ analyses to identify immunohistochemical expression of PBXIP1 in normal and colorectal cancer tissues and biostatistical approaches to determine its function and regulatory correlations. Article Title: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Article Snippet: 1Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.. 2Discovery 1 team, GI Innovation, Seoul, Korea.. 3Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Korea. Article Title: Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair Article Snippet: Heat maps were constructed using GENE-E software (The Broad Institute, www.broadinstitute.org/cancer/software/GENE-E/ ). Article Title: Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Article Snippet: Prostate cancer patients primarily receive androgen receptor (AR)-targeted drugs as a primary treatment option because prostate cancer is associated with highly activated AR signaling.. AR amplification made prostate cancer cells viable under treatment of AR-targeted therapy, leading to castration resistance.. AR amplification was more common in enzalutamide-resistant patients. Article Title: Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters Article Snippet: Heat maps were generated using the GENE-E software (Broad Institute, Cambridge, MA, USA). Expressing:Article Title: Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications Article Snippet: Normalized expression data were Log 2 transformed and loaded into the Gene-E software (v. 3.0.215, Broad Institute © 2013). Article Title: Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. Article Snippet: Based on previous reports on the significance of halogen moieties and the indenopyridin-5-one skeleton, we designed and synthesized a novel series of halogen (F , Cl , Br , CF3 and OCF3 )-containing 2,4diphenyl indenopyridin-5-ones and their corresponding -5-ols.. Unlike indenopyridin-5-ols, most of the prepared indenopyridin-5-ones with Cl , Br , and CF3 groups at the 2-phenyl ring conferred a strong dual topoisomerase I/IIa inhibitory effect.. Among the series, para-bromophenyl substituted compound 9 exhibited the most potent topoisomerase inhibition and antiproliferative effects, which showed dependency upon the topoisomerase gene expression level of diverse cancer cells. Article Title: Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL -Rearranged Acute Lymphoblastic Leukemia Article Snippet: Heatmaps were generated using Gene-E software (Broad Institute, Cambridge, MA, USA). Article Title: PBXIP1 - An indicator for poor outcome and metastatic spread in colorectal cancer. Article Snippet: Tumor cell heterogeneity in colorectal cancers within the same genetic background is a well-described phenomenon.. In this work, we investigate the role of hematopoietic pre-B-cell leukemia transcription factor (PBX)interacting protein (HPIP/PBXIP1) in tumor cell subpopulations with differential Wingless-related integration site (WNT) activity as well as its potential associations with epithelial-mesenchymal transition (EMT) and clinical associations in colorectal cancer.. We used in situ analyses to identify immunohistochemical expression of PBXIP1 in normal and colorectal cancer tissues and biostatistical approaches to determine its function and regulatory correlations. Article Title: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Article Snippet: 1Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.. 2Discovery 1 team, GI Innovation, Seoul, Korea.. 3Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Korea. Article Title: Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair Article Snippet: Heat maps were constructed using GENE-E software (The Broad Institute, www.broadinstitute.org/cancer/software/GENE-E/ ). Article Title: Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Article Snippet: Prostate cancer patients primarily receive androgen receptor (AR)-targeted drugs as a primary treatment option because prostate cancer is associated with highly activated AR signaling.. AR amplification made prostate cancer cells viable under treatment of AR-targeted therapy, leading to castration resistance.. AR amplification was more common in enzalutamide-resistant patients. Article Title: Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters Article Snippet: Heat maps were generated using the GENE-E software (Broad Institute, Cambridge, MA, USA). Transformation Assay:Article Title: Role of FGF Receptors and Their Pathways in Adrenocortical Tumors and Possible Therapeutic Implications Article Snippet: Normalized expression data were Log 2 transformed and loaded into the Gene-E software (v. 3.0.215, Broad Institute © 2013). Article Title: Identification of new halogen-containing 2,4-diphenyl indenopyridin-5-one derivative as a boosting agent for the anticancer responses of clinically available topoisomerase inhibitors. Article Snippet: Based on previous reports on the significance of halogen moieties and the indenopyridin-5-one skeleton, we designed and synthesized a novel series of halogen (F , Cl , Br , CF3 and OCF3 )-containing 2,4diphenyl indenopyridin-5-ones and their corresponding -5-ols.. Unlike indenopyridin-5-ols, most of the prepared indenopyridin-5-ones with Cl , Br , and CF3 groups at the 2-phenyl ring conferred a strong dual topoisomerase I/IIa inhibitory effect.. Among the series, para-bromophenyl substituted compound 9 exhibited the most potent topoisomerase inhibition and antiproliferative effects, which showed dependency upon the topoisomerase gene expression level of diverse cancer cells. Article Title: Irinotecan Induces Disease Remission in Xenograft Mouse Models of Pediatric MLL -Rearranged Acute Lymphoblastic Leukemia Article Snippet: Heatmaps were generated using Gene-E software (Broad Institute, Cambridge, MA, USA). Article Title: PBXIP1 - An indicator for poor outcome and metastatic spread in colorectal cancer. Article Snippet: Tumor cell heterogeneity in colorectal cancers within the same genetic background is a well-described phenomenon.. In this work, we investigate the role of hematopoietic pre-B-cell leukemia transcription factor (PBX)interacting protein (HPIP/PBXIP1) in tumor cell subpopulations with differential Wingless-related integration site (WNT) activity as well as its potential associations with epithelial-mesenchymal transition (EMT) and clinical associations in colorectal cancer.. We used in situ analyses to identify immunohistochemical expression of PBXIP1 in normal and colorectal cancer tissues and biostatistical approaches to determine its function and regulatory correlations. Article Title: TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Article Snippet: 1Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.. 2Discovery 1 team, GI Innovation, Seoul, Korea.. 3Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of Medicine, Incheon, Korea. Article Title: Loss of hepatic Sirt7 accelerates diethylnitrosamine (DEN)-induced formation of hepatocellular carcinoma by impairing DNA damage repair Article Snippet: Heat maps were constructed using GENE-E software (The Broad Institute, www.broadinstitute.org/cancer/software/GENE-E/ ). Article Title: Synthesis and evaluation of 7-(3-aminopropyloxy)-substituted flavone analogue as a topoisomerase IIα catalytic inhibitor and its sensitizing effect to enzalutamide in castration-resistant prostate cancer cells. Article Snippet: Prostate cancer patients primarily receive androgen receptor (AR)-targeted drugs as a primary treatment option because prostate cancer is associated with highly activated AR signaling.. AR amplification made prostate cancer cells viable under treatment of AR-targeted therapy, leading to castration resistance.. AR amplification was more common in enzalutamide-resistant patients. Article Title: Dual Targeting of EGFR with PLK1 Exerts Therapeutic Synergism in Taxane-Resistant Lung Adenocarcinoma by Suppressing ABC Transporters Article Snippet: Heat maps were generated using the GENE-E software (Broad Institute, Cambridge, MA, USA). |